Regulation of tissue repair, mucosal barrier function and metabolism are essential to maintain gut homeostasis. Innate lymphoid cells (ILCs), positionally located at the body’s surfaces, are ideally situated to integrate the vast number of signals encountered by an organism and to trigger robust protection of the body from pathogen invasion. Intestinal T cells and group 3 ILCs (ILC3s) control the composition of the microbiota and gut immune responses. Neuroimmune circuits, cellular rhythms together with various inhibitory and activatory receptors expressed by ILC3 determine their functional capacity and provide a mechanism of integrating the complex information necessary to tailor immune responses. We aim to investigate how the physiological hubs establish rheostats of innate cell function to enforce barrier protection.